Characteristics of Follicular Variant Papillary Thyroid Carcinoma in a Pediatric Cohort.

TitleCharacteristics of Follicular Variant Papillary Thyroid Carcinoma in a Pediatric Cohort.
Publication TypeJournal Article
Year of Publication2018
AuthorsSamuels SL, Surrey LF, Hawkes CP, Amberge M, Mostoufi-Moab S, Langer JE, N Adzick S, Kazahaya K, Bhatti T, Baloch ZW, LiVolsi VA, Bauer AJ
JournalJ Clin Endocrinol Metab
Start Page1639
Date Published2018 Apr 1

Context: In adults, non-invasive follicular variant papillary thyroid carcinoma (FVPTC) is considered low risk for metastasis and persistent/recurrent disease.

Objective: The goal of this study was to assess the clinical, sonographic, and histopathological features of FVPTC in a pediatric cohort.

Design: A retrospective review of subjects < 19 years of age with papillary thyroid carcinoma (PTC) who underwent thyroidectomy between January 2010 and July 2015.

Setting: Multidisciplinary, academic referral center.

Patients: Patients with FVPTC, defined as a tumor ≥1.0 cm in largest dimension with predominant follicular growth, complete lack of well-formed papillae, and nuclear features of PTC.

Main Outcome Measure: Tumor size and location, presence of a tumor capsule, capsule and vascular invasion, lymph node and distant metastasis.

Results: Eighteen patients with FVPTC were identified from a case cohort of 110 patients with PTC. On histopathology, 13 (72%) had unifocal nodules and 14 (78%) were completely encapsulated. Capsule invasion was frequent (9/14; 64%) and vascular invasion was found in one third of patients (6/18; 33%). No lymph node metastases were found in the 13 (72%) patients who had a central neck lymph node dissection. One patient with vascular invasion had distant metastases.

Conclusion: When strictly defined, FVPTC in pediatric patients has a low risk for bilateral disease and metastasis. Prospective studies are needed to confirm whether lobectomy with surveillance is sufficient to achieve remission in pediatric patients with low risk FVPTC.

PubMed ID29438531