Candidemia in children: Epidemiology, prevention and management.

TitleCandidemia in children: Epidemiology, prevention and management.
Publication TypeJournal Article
Year of Publication2018
AuthorsMantadakis E, Pana ZDorothea, Zaoutis T
JournalMycoses
Volume61
Issue9
Pagination614-622
Date Published2018 Sep
ISSN1439-0507
KeywordsAdult, Candidemia, Cross Infection, Disease Management, Global Health, Humans, Incidence, Infant, Infant, Newborn, Infection Control, Young Adult
Abstract

Candidemia is the leading cause of invasive fungal infections in hospitalised children. The highest rates of candidemia have been recorded in neonates and infants <1 year of age. Candidemia is more frequent in neonates and young infants than in adults, and is associated with better clinical outcomes, but higher inpatient costs. Over the last 10 years, a declining trend has been noted in the incidence of paediatric candidemia in the US and elsewhere due to the hospital-wide implementation of central-line insertion and maintenance bundles that emphasise full sterile barrier precautions, chlorhexidine skin preparation during line insertion, meticulous site and tubing care, and daily discussion of catheter necessity. Additional interventions aiming at reducing gut-associated candidemia are required in immunocompromised and critically ill children.

DOI10.1111/myc.12792
Alternate JournalMycoses
PubMed ID29762868