Brief Report: Apparent Antiretroviral Over-adherence by Pill Count is Associated with HIV Treatment Failure in Adolescents.

TitleBrief Report: Apparent Antiretroviral Over-adherence by Pill Count is Associated with HIV Treatment Failure in Adolescents.
Publication TypeJournal Article
Year of Publication2016
AuthorsOkatch H, Beiter K, Eby J, Chapman J, Marukutira T, Tshume O, Matshaba M, Anabwani GM, Gross R, Lowenthal ED
JournalJ Acquir Immune Defic Syndr
Date Published2016 Mar 16
ISSN1944-7884
Abstract

Pill counts with calculated adherence percentages are used in many settings to monitor adherence, but can be undermined by patients discarding pills to hide non-adherence. Pill counts suggesting that >100% of prescribed doses were taken can signal "pill dumping." We defined "over-adherence" (OA) among a cohort of 300 HIV-infected adolescents as having >1/3 of pill counts with >100% adherence during a year of follow-up. Apparent over-adherence was more common in those with virologic failure than those with suppressed viral loads (33% vs 13%, chi p=0.001). Pill count adherence repeatedly >100% may identify HIV-infected adolescents at increased risk of treatment failure.

DOI10.1097/QAI.0000000000000994
Alternate JournalJ. Acquir. Immune Defic. Syndr.
PubMed ID26990822
Grant ListK23 MH095669 / MH / NIMH NIH HHS / United States
L40 AI090971 / AI / NIAID NIH HHS / United States