Bortezomib Inpatient Prescribing Practices in Free-Standing Children's Hospitals in the United States.

TitleBortezomib Inpatient Prescribing Practices in Free-Standing Children's Hospitals in the United States.
Publication TypeJournal Article
Year of Publication2016
AuthorsDiNofia AM, Salazar EG, Seif AE, Li Y, Huang Y-SVera, Bagatell R, Fisher BT, Aplenc R
JournalPLoS One
Volume11
Issue3
Paginatione0151362
Date Published2016
ISSN1932-6203
Abstract

This study is a pharmacoepidemiologic description of pediatric bortezomib use. Exposure was identified through billing codes in patients admitted to US children's hospitals that participated with the Pediatric Health Information System between 2004 and 2013. Associated information on underlying diseases, demographics, institutional use, mortality, and physician type was collected. Exposure to bortezomib was identified in 314 patients. Hematologist/Oncologists prescribed half of the bortezomib used. Use increased during the study period. Inpatient volume was positively correlated with bortezomib utilization. Bortezomib use in pediatrics is increasing for a variety of diseases. Variation in use exists across institutions. Further studies are needed to characterize bortezomib's efficacy in pediatric diseases.

DOI10.1371/journal.pone.0151362
Alternate JournalPLoS ONE
PubMed ID26978062
PubMed Central IDPMC4792468