| Title | Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Mostoufi-Moab S, Halton J |
| Journal | Curr Osteoporos Rep |
| Volume | 12 |
| Issue | 3 |
| Pagination | 300-12 |
| Date Published | 2014 Sep |
| ISSN | 1544-2241 |
| Keywords | Bone Diseases, Child, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Osteonecrosis, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Spinal Fractures |
| Abstract | Skeletal abnormalities are commonly seen in children and adolescents with leukemia. The spectrum ranges from mild pain to debilitating osteonecrosis (ON) and fractures. In this review, we summarize the skeletal manifestations, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life observed in children and adolescents with leukemia. |
| DOI | 10.1007/s11914-014-0222-3 |
| Alternate Journal | Curr Osteoporos Rep |
| PubMed ID | 24986711 |
| PubMed Central ID | PMC4131149 |
| Grant List | K07 CA166177 / CA / NCI NIH HHS / United States |