Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment.

TitleBone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment.
Publication TypeJournal Article
Year of Publication2014
AuthorsMostoufi-Moab S, Halton J
JournalCurr Osteoporos Rep
Volume12
Issue3
Pagination300-12
Date Published2014 Sep
ISSN1544-2241
KeywordsBone Diseases, Child, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Osteonecrosis, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Spinal Fractures
Abstract

Skeletal abnormalities are commonly seen in children and adolescents with leukemia. The spectrum ranges from mild pain to debilitating osteonecrosis (ON) and fractures. In this review, we summarize the skeletal manifestations, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life observed in children and adolescents with leukemia.

DOI10.1007/s11914-014-0222-3
Alternate JournalCurr Osteoporos Rep
PubMed ID24986711
PubMed Central IDPMC4131149
Grant ListK07 CA166177 / CA / NCI NIH HHS / United States