Bone Health in Glomerular Kidney Disease.

TitleBone Health in Glomerular Kidney Disease.
Publication TypeJournal Article
Year of Publication2019
AuthorsGlenn DA, Denburg MR
JournalCurr Osteoporos Rep
Date Published2019 Nov 16
ISSN1544-2241
Abstract

PURPOSE OF REVIEW: To summarize the literature regarding alterations in bone health in patients with glomerular kidney disease and highlight areas in need of additional investigation.

RECENT FINDINGS: There is mounting evidence that children and adults with glomerular conditions, with or without compromised kidney function, comprise a distinct subgroup of patients with unique risk factors for altered bone health. Patients with glomerular kidney disease are exposed to both disease-related and treatment-related factors that affect bone structure and function. In addition to chronic kidney disease-related risk factors for impaired bone health, high rates of exposure to osteotoxic medications, varying degrees of systemic inflammation, and altered vitamin D metabolism may contribute to compromised bone health in individuals with glomerular disease. Further study is needed to better understand these risk factors and the complex interaction between the immune system and bone cells in glomerular disease.

DOI10.1007/s11914-019-00531-z
Alternate JournalCurr Osteoporos Rep
PubMed ID31734906