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|Title||Bacterial and cytokine mixtures predict the length of gestation and are associated with miRNA expression in the cervix.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Sanders AP, Gennings C, Svensson K, Motta V, Mercado-Garcia A, Solano M, Baccarelli AA, Tellez-Rojo MM, Wright RO, Burris HH|
|Date Published||2017 01|
|Keywords||Adolescent, Adult, Biomarkers, Cervix Uteri, Cytokines, Female, Humans, MicroRNAs, Pregnancy, Pregnancy Complications, Infectious, Premature Birth, RNA, Messenger, Vaginosis, Bacterial|
AIM: Bacterial vaginosis may lead to preterm birth through epigenetic programming of the inflammatory response, specifically via miRNA expression.
METHODS: We quantified bacterial 16S rRNA, cytokine mRNA and 800 miRNA from cervical swabs obtained from 80 women at 16-19 weeks' gestation. We generated bacterial and cytokine indices using weighted quantile sum regression and examined associations with miRNA and gestational age at delivery.
RESULTS & DISCUSSION: Each decile of the bacterial and cytokine indices was associated with shorter gestations (p < 0.005). The bacterial index was associated with miR-494, 371a, 4286, 185, 320e, 888 and 23a (p < 0.05). miR-494 remained significant after false discovery rate correction (q < 0.1). The cytokine index was associated with 27 miRNAs (p < 0.05; q < 0.01).
CONCLUSION: Future investigation into the role of bacterial vaginosis- and inflammation-associated miRNA and preterm birth is warranted.
|PubMed Central ID||PMC5514975|
|Grant List||R01 ES021357 / ES / NIEHS NIH HHS / United States |
P30 ES000002 / ES / NIEHS NIH HHS / United States
R01 ES013744 / ES / NIEHS NIH HHS / United States
P30 ES023515 / ES / NIEHS NIH HHS / United States
R01 ES014930 / ES / NIEHS NIH HHS / United States
R01 ES020268 / ES / NIEHS NIH HHS / United States
K23 ES022242 / ES / NIEHS NIH HHS / United States
P30 ES009089 / ES / NIEHS NIH HHS / United States