Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952.

TitleAssociations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952.
Publication TypeJournal Article
Year of Publication2015
AuthorsVujkovic M, Kershenbaum A, Wray L, McWilliams T, Cannon S, Devidas M, Stork L, Aplenc R
JournalLeuk Res Rep
Volume4
Issue2
Pagination47-50
Date Published2015
ISSN2213-0489
Abstract

Genetic variation in drug detoxification pathways may influence outcomes in pediatric acute lymphoblastic leukemia (ALL). We evaluated relapse risk and 24 variants in 17 genes in 714 patients in CCG-1961. Three TPMT and 1 MTR variant were associated with increased risks of relapse (rs4712327, OR 3.3, 95%CI 1.2-8.6; rs2842947, OR 2.7, 95%CI 1.1-6.8; rs2842935, OR 2.5, 95%CI 1.1-5.0; rs10925235, OR 4.9, 95%CI 1.1-25.1). One variant in SLC19A1 showed a protective effect (rs4819128, OR 0.5, 95%CI 0.3-0.9). Our study provides data that relapse risk in pediatric ALL is associated with germline variations in TPMT, MTR and SLC19A1.

DOI10.1016/j.lrr.2015.05.005
Alternate JournalLeuk Res Rep
PubMed ID26605150
PubMed Central IDPMC4621538
Grant ListR01 CA108862 / CA / NCI NIH HHS / United States
R01 CA133881 / CA / NCI NIH HHS / United States