Title | Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Vujkovic M, Kershenbaum A, Wray L, McWilliams T, Cannon S, Devidas M, Stork L, Aplenc R |
Journal | Leuk Res Rep |
Volume | 4 |
Issue | 2 |
Pagination | 47-50 |
Date Published | 2015 |
ISSN | 2213-0489 |
Abstract | Genetic variation in drug detoxification pathways may influence outcomes in pediatric acute lymphoblastic leukemia (ALL). We evaluated relapse risk and 24 variants in 17 genes in 714 patients in CCG-1961. Three TPMT and 1 MTR variant were associated with increased risks of relapse (rs4712327, OR 3.3, 95%CI 1.2-8.6; rs2842947, OR 2.7, 95%CI 1.1-6.8; rs2842935, OR 2.5, 95%CI 1.1-5.0; rs10925235, OR 4.9, 95%CI 1.1-25.1). One variant in SLC19A1 showed a protective effect (rs4819128, OR 0.5, 95%CI 0.3-0.9). Our study provides data that relapse risk in pediatric ALL is associated with germline variations in TPMT, MTR and SLC19A1. |
DOI | 10.1016/j.lrr.2015.05.005 |
Alternate Journal | Leuk Res Rep |
PubMed ID | 26605150 |
PubMed Central ID | PMC4621538 |
Grant List | R01 CA108862 / CA / NCI NIH HHS / United States R01 CA133881 / CA / NCI NIH HHS / United States |