Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis.

TitleAssociation of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis.
Publication TypeJournal Article
Year of Publication2019
AuthorsAronson PL, Cruz AT, Freedman SB, Balamuth F, Grether-Jones KL, Lyons TW, Fleming AH, Louie J, Mistry RD, Garro AC, Shah SS, Nigrovic LE
Corporate AuthorsPediatric Emergency Medicine Clinical Research Network(PEM CRC) Herpes Simplex Virus(HSV) Study Group
JournalJ Hosp Med
Volume14
PaginationE1-E4
Date Published2019 May 12
ISSN1553-5606
Abstract

Although neonatal herpes simplex virus (HSV) causes significant morbidity, utilization of the cerebrospinal fluid (CSF) HSV polymerase chain reaction (PCR) test remains variable. Our objective was to examine the association of CSF HSV PCR testing with length of stay (LOS) in a 20-center retrospective cohort of hospitalized infants aged ≤60 days undergoing evaluation for meningitis after adjustment for patient-level factors and clustering by center. Of 20,496 eligible infants, 7,399 (36.1%) had a CSF HSV PCR test performed, and 46 (0.6% of those tested) had a positive test. Infants who had a CSF HSV PCR test performed had a 23% longer hospital LOS (incident rate ratio 1.23; 95% CI: 1.14-1.33). Targeted CSF HSV PCR testing may mitigate the impact on LOS for low-risk infants.

DOI10.12788/jhm.3202
Alternate JournalJ Hosp Med
PubMed ID31112493