Association of a blood culture utilization intervention on antibiotic use in a pediatric intensive care unit.

TitleAssociation of a blood culture utilization intervention on antibiotic use in a pediatric intensive care unit.
Publication TypeJournal Article
Year of Publication2019
AuthorsSick-Samuels AC, Woods-Hill CZ, Fackler JC, Tamma PD, Klaus SA, Colantuoni EE, Milstone AM
JournalInfect Control Hosp Epidemiol
Volume40
Issue4
Pagination482-484
Date Published2019 04
ISSN1559-6834
KeywordsAnti-Bacterial Agents, Blood Culture, Drug Utilization, Humans, Intensive Care Units, Pediatric, Pediatrics, Quality Improvement, Retrospective Studies, Sepsis
Abstract

Blood cultures are essential for the evaluation of sepsis. However, they may sometimes be obtained inappropriately, leading to high false-positive rates, largely due to contamination.1 As a quality improvement project, clinician decision-support tools for evaluating patients with fever or signs and symptoms of sepsis were implemented in April 2014 in our pediatric intensive care unit (PICU). This initiative resulted in a 46% decrease in blood culture obtainment2 and has been replicated in other institutions.3 It is important to evaluate antibiotic use as a balancing measure because a reduction in blood cultures could lead to an increase in antibiotic treatment days if clinicians continued empiric treatment in scenarios when blood culture results were not available. The objective of this study was to evaluate whether antibiotic use in the PICU changed in association with a reduction in blood culture utilization.

DOI10.1017/ice.2019.10
Alternate JournalInfect Control Hosp Epidemiol
PubMed ID30767809
PubMed Central IDPMC6459704
Grant ListK24 AI141580 / AI / NIAID NIH HHS / United States
R18 HS025642 / HS / AHRQ HHS / United States
T32 AI052071 / AI / NIAID NIH HHS / United States