- Research Methods &
- Research Training
- Research Into
|Title||Association between Daily Water Intake and 24-hour Urine Volume Among Adolescents with Kidney Stones.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Bernard J, Song L, Henderson B, Tasian GE|
|Date Published||2020 Jan 28|
OBJECTIVE: To determine the association between daily water intake and 24-hour urine volume among adolescents with nephrolithiasis in order to estimate a "fluid prescription", the additional water intake needed to increase urine volume to a target goal.
METHODS: We conducted a secondary analysis of an ecological momentary assessment study that prospectively measured daily water intake of 25 adolescents with nephrolithiasis over 7 days. We identified 24-hour urine volumes obtained for clinical care within 12 months of water intake assessment. A linear regression model was fit to estimate the magnitude of the association between daily water intake and 24-hour urine volume, adjusting for age, sex, race, and daily temperature.
RESULTS: Twenty-two participants completed fifty-seven 24-hour urine collections within 12 months of the study period. Median daily water intake was 1.4 L (IQR 0.67-1.94). Median 24-hour urine volume was 2.01 L (IQR 1.20-2.73). A 1 L increase in daily water intake was associated with a 710 mL increase in 24-hour urine output (95% CI 0.55-0.87). Using the model output, the equation was generated to estimate the additional fluid intake needed (fluid prescription; FP) to produce the desired increase in urine output (dUOP): FP=dUOP/0.71.
CONCLUSIONS: The fluid prescription equation (FP = dUOP)/0.71), which reflects the relationship between water intake and urine volume, could be used to help adolescents with nephrolithiasis achieve urine output goals to decrease stone recurrence.