Assessment of primary outcome measures for a clinical trial of pediatric hemorrhagic injuries.

TitleAssessment of primary outcome measures for a clinical trial of pediatric hemorrhagic injuries.
Publication TypeJournal Article
Year of Publication2020
AuthorsNishijima DK, Gosdin M, Naz H, Tancredi DJ, Hewes HA, Myers SR, Stanley RM, P Adelson D, Burd RS, Finkelstein Y, VanBuren J, T Casper C, Kuppermann N
Corporate AuthorsTIC-TOC Collaborators of the Pediatric Emergency Care Applied Research Network(PECARN)
JournalAm J Emerg Med
Date Published2020 Mar 09
ISSN1532-8171
Abstract

OBJECTIVE: We evaluated the acceptability of the Pediatric Quality of Life Inventory (PedsQL) and other outcomes as the primary outcomes for a pediatric hemorrhagic trauma trial (TIC-TOC) among clinicians.

METHODS: We conducted a mixed-methods study that included an electronic questionnaire followed by teleconference discussions. Participants confirmed or rejected the PedsQL as the primary outcome for the TIC-TOC trial and evaluated and proposed alternative primary outcomes. Responses were compiled and a list of themes and representative quotes was generated.

RESULTS: 73 of 91 (80%) participants completed the questionnaire. 61 (84%) participants agreed that the PedsQL is an appropriate primary outcome for children with hemorrhagic brain injuries. 32 (44%) participants agreed that the PedsQL is an acceptable primary outcome for children with hemorrhagic torso injuries, 27 (38%) participants were neutral, and 13 (18%) participants disagreed. Several themes were identified from responses, including that the PedsQL is an important and patient-centered outcome but may be affected by other factors, and that intracranial hemorrhage progression assessed by brain imaging (among patients with brain injuries) or blood product transfusion requirements (among patients with torso injuries) may be more objective outcomes than the PedsQL.

CONCLUSIONS: The PedsQL was a well-accepted proposed primary outcome for children with hemorrhagic brain injuries. Traumatic intracranial hemorrhage progression was favored by a subset of clinicians. A plurality of participants also considered the PedsQL an acceptable outcome for children with hemorrhagic torso injuries. Blood product transfusion requirement was favored by fewer participants.

DOI10.1016/j.ajem.2020.03.001
Alternate JournalAm J Emerg Med
PubMed ID32278572
Grant ListR34 HL135214 / HL / NHLBI NIH HHS / United States