| Title | Assembly of a cohort of children treated for acute myeloid leukemia at free-standing children's hospitals in the United States using an administrative database. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Kavcic M, Fisher BT, Torp K, Li Y, Huang YS, Seif AE, Vujkovic M, Aplenc R |
| Journal | Pediatr Blood Cancer |
| Volume | 60 |
| Issue | 3 |
| Pagination | 508-11 |
| Date Published | 2013 Mar |
| ISSN | 1545-5017 |
| Keywords | Child, Cohort Studies, Databases, Factual, Health Information Systems, Hospitals, Pediatric, Humans, International Classification of Diseases, Leukemia, Myeloid, Acute, SEER Program, United States |
| Abstract | Pediatric Health Information System data were used to establish a multi-center cohort of 1,686 children treated for newly diagnosed acute myeloid leukemia (AML). The cohort assembly process, which included myeloid leukemia ICD-9 discharge diagnosis codes and manual review of induction chemotherapy, was validated by chart review at a single institution. The use of ICD-9 codes alone resulted in a poor positive predictive value (PPV; 31%). Inclusion of the results from the chemotherapy review improved the PPV to 100% without compromising sensitivity (95.7%). This cohort provides a reliable source for future comparative effectiveness and clinical epidemiology studies in pediatric AML. |
| DOI | 10.1002/pbc.24402 |
| Alternate Journal | Pediatr Blood Cancer |
| PubMed ID | 23192853 |
| PubMed Central ID | PMC3684426 |
| Grant List | R01 CA133881 / CA / NCI NIH HHS / United States R01 CA165277 / CA / NCI NIH HHS / United States R01CA165277 / CA / NCI NIH HHS / United States |