Assembly of a cohort of children treated for acute myeloid leukemia at free-standing children's hospitals in the United States using an administrative database.

TitleAssembly of a cohort of children treated for acute myeloid leukemia at free-standing children's hospitals in the United States using an administrative database.
Publication TypeJournal Article
Year of Publication2013
AuthorsKavcic M, Fisher BT, Torp K, Li Y, Huang YS, Seif AE, Vujkovic M, Aplenc R
JournalPediatr Blood Cancer
Volume60
Issue3
Pagination508-11
Date Published2013 Mar
ISSN1545-5017
KeywordsChild, Cohort Studies, Databases, Factual, Health Information Systems, Hospitals, Pediatric, Humans, International Classification of Diseases, Leukemia, Myeloid, Acute, SEER Program, United States
Abstract

Pediatric Health Information System data were used to establish a multi-center cohort of 1,686 children treated for newly diagnosed acute myeloid leukemia (AML). The cohort assembly process, which included myeloid leukemia ICD-9 discharge diagnosis codes and manual review of induction chemotherapy, was validated by chart review at a single institution. The use of ICD-9 codes alone resulted in a poor positive predictive value (PPV; 31%). Inclusion of the results from the chemotherapy review improved the PPV to 100% without compromising sensitivity (95.7%). This cohort provides a reliable source for future comparative effectiveness and clinical epidemiology studies in pediatric AML.

DOI10.1002/pbc.24402
Alternate JournalPediatr Blood Cancer
PubMed ID23192853
PubMed Central IDPMC3684426
Grant ListR01 CA133881 / CA / NCI NIH HHS / United States
R01 CA165277 / CA / NCI NIH HHS / United States
R01CA165277 / CA / NCI NIH HHS / United States