Antibiotic stewardship in the intensive care unit: Challenges and opportunities.

TitleAntibiotic stewardship in the intensive care unit: Challenges and opportunities.
Publication TypeJournal Article
Year of Publication2019
AuthorsChiotos K, Tamma PD, Gerber JS
JournalInfect Control Hosp Epidemiol
Date Published2019 May 03

Infections due to antibiotic-resistant organisms are increasing in prevalence and represent a major public health threat. Antibiotic overuse is a major driver of this epidemic, and antibiotic stewardship an important means of limiting antibiotic resistance. The intensive care unit (ICU) setting presents an intersection of opportunities and challenges for effective antibiotic stewardship, but limited data inform optimal stewardship interventions in this setting. In this review, we present unique considerations for stewardship interventions the ICU setting and summarize available data evaluating the impact of prospective audit and feedback, diagnostic test stewardship, rapid molecular diagnostic tests, and procalcitonin-guided algorithms for antibiotic discontinuation. The existing knowledge gaps ripe for future research are emphasized.

Alternate JournalInfect Control Hosp Epidemiol
PubMed ID31046851