Akkermansia muciniphila is permissive to arthritis in the K/BxN mouse model of arthritis.

TitleAkkermansia muciniphila is permissive to arthritis in the K/BxN mouse model of arthritis.
Publication TypeJournal Article
Year of Publication2019
AuthorsStoll ML, M Pierce K, Watkins JA, Zhang M, Weiss PF, Weiss JE, Elson CO, Cron RQ, Kumar R, Morrow CD, Schoeb TR
JournalGenes Immun
Volume20
Issue2
Pagination158-166
Date Published2019 02
ISSN1476-5470
KeywordsAdolescent, Animals, Ankle, Arthritis, Bacteroides, Child, Female, Gastrointestinal Microbiome, Humans, Male, Mice, Mice, Inbred NOD, Verrucomicrobia
Abstract

Studies have identified abnormalities in the microbiota of patients with arthritis. To evaluate the pathogenicity of human microbiota, we performed fecal microbial transplantation from children with spondyloarthritis and controls to germ-free KRN/B6xNOD mice. Ankle swelling was equivalent in those that received patient vs. control microbiota. Principal coordinates analysis revealed incomplete uptake of the human microbiota with over-representation of two genera (Bacteroides and Akkermansia) among the transplanted mice. The microbiota predicted the extent of ankle swelling (R2 = 0.185, p = 0.018). The abundances of Bacteroides (r = -0.510, p = 0.010) inversely and Akkermansia (r = 0.367, p = 0.078) directly correlated with ankle swelling. Addition of Akkermansia muciniphila to Altered Schaedler's Flora (ASF) resulted in small but statistically significant increased ankle swelling as compared to mice that received ASF alone (4.0 mm, 3.9-4.1 vs. 3.9 mm, IQR 3.6-4.0, p = 0.041), as did addition of A. muciniphila cultures to transplanted human microbiota as compared to mice that received transplanted human microbiota alone (4.5 mm, IQR 4.3-5.5 vs. 4.1 mm, IQR 3.9-4.3, p = 0.019). This study supports previous findings of an association between A. muciniphila and arthritis.

DOI10.1038/s41435-018-0024-1
Alternate JournalGenes Immun.
PubMed ID29599513
PubMed Central IDPMC6153082
Grant ListP30 AR050948 / AR / NIAMS NIH HHS / United States
P60 AR064172 / AR / NIAMS NIH HHS / United States
R21 ES024413 / ES / NIEHS NIH HHS / United States
UL1 TR001417 / TR / NCATS NIH HHS / United States