Care of Chronically/Seriously Ill or Injured Children

The Children’s Hospital of Philadelphia (CHOP) is consistently ranked among the nation’s best children’s hospitals by U.S. World and News Report; for the 2015-2016 rankings, all 10 of CHOP’s specialties that were considered were ranked in the top six out of 109 hospitals. This is due, in part, to the remarkable patient outcomes achieved despite treating the most seriously ill children in our our own community, as well as those infants and children referred to CHOP from other hospitals due to their significant, complex conditions.

CPCE’s investigators are also members of CHOP’s clinical staff and strive to provide optimal care for all CHOP patients. Among these are children who suffer from chronic illness or serious illness or injuries. Providing a high standard of care for the diagnosis, treatment, and recovery of these children – in areas ranging from Oncology to Rheumatology to Urology, and beyond – drives CPCE’s research efforts.

Palliative care has a simple goal: to improve the quality of life for seriously ill patients and their families. CPCE’s research aims to close knowledge gaps and build a scientific foundation for better long-term outcomes for these patients.

Areas of Research on Chronic Illness, Serious Illness and Injury in Children

Shared Decision Making for Critically Ill Pediatric Patients | CPCE

Shared Decision-making for Critically Ill Pediatric Patients -- Shared decision-making for critically ill pediatric patients research looks at the impact of continuity of intensive care attending physicians for longer-stay patients admitted to the pediatric intensive care unit (PICU). This research explores both patient outcomes and family satisfaction with decision-making support. 

Palliative Care | CPCE

Pediatric Palliative Care -- Pediatric palliative or advanced care is focused on providing relief from pain, symptoms or stress related to a chronic and/or life-threatening illness. This area of research explores the comparative effectiveness and safety of hospital-based pediatric palliative care.

Pediatric Oncology Education and Care | CPCE

Pediatric Oncology Care -- Oncology care research at CPCE focuses on improving the outcomes of pediatric cancer patients by investigating and identifying ways to improve treatment. Research areas of interest include variation of care across institutions, genetic predictors of treatment responses, and risk factors for treatment complications.

Child Abuse/Maltreatment | CPCE

Child Abuse and Maltreatment -- CPCE researchers are focusing on improving quality of care delivered within the medical and child welfare systems to suspected victims of child maltreatment, specifically improving occult injury screening practices through developing and testing clinical guidelines.

Mental Health in Hospitalized Children

Mental Health in Hospitalized Children -- Mental health research at CPCE focuses on understanding how mental health conditions and mental health symptoms influence hospital outcomes, and what interventions can ensure best-possible hospital outcomes for all children regardless of mental health status.

HIV Treatment and Care

Pediatric HIV Treatment -- This area of research addresses specific challenges relating to the care and treatment of children and adolescents with HIV, including treatment adherence, to improve outcomes and guide clinical care.


Neonatal Intensive Care -- Neonatal intensive care (NICU) research at CPCE focuses on preventing infection in newborns by improving evaluation and recommending appropriate antibiotic use.

Care of Patients with Rheumatological Conditions | CPCE

Pediatric Rheumatology Research -- CPCE’s research aims to improve clinical care and physical and mental health outcomes for children with rheumatic disease by addressing critical knowledge gaps in understudied rheumatic conditions, evaluating the effectiveness of treatment strategies for newly diagnosed children, and investigating the psychosocial impact of disease. Diseases of focus include juvenile spondyloarthritis, juvenile idiopathic arthritis, and lupus.

Pediatric Kidney Stones Research | CPCE

Pediatric Kidney Stones -- The incidence of pediatric kidney stones has increased dramatically over the last 25 years for reasons that are not well-described. This has resulted in uncertainty of how to best evaluate children with suspected kidney stones and how to effectively decrease recurrence for patients whose first stone developed during childhood. This line of CPCE research seeks to close these knowledge gaps.

Chronic Kidney Disease | CPCE

Pediatric Chronic Kidney Disease -- CPCE’s research in this area focuses on the early identification of children at high risk for chronic kidney disease, which has increased in incidence in the pediatric population over the past two decades.