Theoklis Zaoutis, MD, MSCE

Core Faculty

Theo Zaoutis, MD, MSCE is a faculty member at Center for Pediatric Clinical Effectiveness (CPCE) at The Children’s Hospital of Philadelphia (CHOP). Dr. Zaoutis served as Director of the CPCE from 2014 to 2019, and as Associate Director for six years before that.

A pediatrician trained in infectious diseases and epidemiology, his research interests include the epidemiology, prevention and treatment of healthcare acquired infections, antimicrobial resistance, and antimicrobial use.

Dr. Zaoutis’ research has been widely published in the leading peer-reviewed journals. He is currently the principal investigator (PI) for a National Institute for Allergy and Infectious Diseases (NIAID) contract, which supports a randomized placebo controlled trial of short course antibiotic therapy for urinary tract infections in children as a strategy to reduce antimicrobial resistance. Dr. Zaoutis’ R01 grant focuses on the comparative effectiveness of antifungal agents for the treatment of candidemia in children. He also serves as co-PI of the first large resource study to be conducted by the newly formed Antimicrobial Leadership Group of NIAID focusing on the treatment of community-acquired pneumonia. In the past, Dr. Zaoutis served as PI of an Agency for Healthcare Research and Quality (AHRQ)- funded cluster-randomized trial of an antimicrobial stewardship intervention.

Dr. Zaoutis is the Werner and Gertrude Henle Endowed Professor of Pediatrics and Professor of Epidemiology at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the Division of Infectious Diseases at CHOP.

Contact Dr. Zaoutis at 267-426-5570 or

To view Dr. Zaoutis' peer-reviewed publications, click here.