Michael O'Byrne, MD, MSCE

Core Faculty

Michael L. O’Byrne, MD, MSCE is a core faculty member at the Center for Pediatric Clinical Effectiveness (CPCE), an Interventional Cardiologist in the Division of Cardiology at The Children’s Hospital of Philadelphia (CHOP), and an Assistant Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.

Dr. O’Byrne’s research focuses on improving outcomes in patients with congenital and acquired heart disease.  This combines use of large observational datasets to assess quality of care and practice variation between hospitals, comparative effectiveness research, and patient-centered outcomes of patients undergoing cardiac procedures and their families. 

Dr. O’Byrne graduated with an AB degree magna cum laude in Neurobiology from Harvard University in in 2001, followed by an MD from Columbia University’s College of Physicians and Surgeons in 2007.  His internship and residency were completed at The Children’s Hospital of Philadelphia, followed by a fellowship in pediatric cardiology and advanced fellowships in pediatric cardiovascular research and interventional cardiology. He completed an MSCE from the University of Pennsylvania in 2014. He re-joined the faculty at CHOP in his current position in 2017.