Goli Mostoufi-Moab, MD, MSCE
Goli Mostoufi-Moab, MD, MSCE is a core faculty member at the Center for Pediatric Clinical Effectiveness at the Children's Hospital of Philadelphia (CHOP) and assistant professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. She is a dual-certified pediatric oncologist and endocrinologist with clinical expertise in endocrine late effects after childhood cancer therapy.
The development of intensified oncology treatment regimens has greatly improved the survival of children with cancer. However, treatment-related disorders of endocrine systems are common in this growing population of cancer survivors. As the endocrinologist for the Cancer Survivorship Program, Dr. Mostoufi-Moab treats childhood cancer survivors with endocrine abnormalities such as abnormal growth, thyroid disorders, pubertal disorders, and thyroid malignancy.
Over the course of her unique dual training, Dr. Mostoufi-Moab developed an interest in understanding childhood bone health and cancer treatment-related threats to childhood skeletal development. Cancer survivors are at risk for poor bone health, given their numerous endocrine morbidities. Skeletal development during childhood is characterized by specific changes in bone dimensions with coordinated actions of growth hormone and sex steroids in the setting of adequate biomechanical loading and nutrition. Chemotherapy, irradiation, steroid exposure, poor muscle strength, vitamin D deficiency and poor nutrition all negatively impact the growing, vulnerable skeleton in this at-risk patient population.
Dr. Mostoufi-Moab's research program focuses on bone health and body composition abnormalities in childhood cancer survivors. Her dual training experience provides unique expertise for treatment of multiple, complex endocrine abnormalities after various childhood cancer regimens such as high risk neuroblastoma treatment.