Translational Clinical Research

CPCE’s translational clinical research applies what we learn in the basic science laboratory to studies in humans to help us accelerate laboratory discoveries into effective treatments for patients. This aligns with The Children's Hospital of Philadelphia Research Institute “bench to bedside” philosophy and CHOP’s  mission to advance the health of children by turning scientific discovery into medical innovation.

T-Phases of Translational Health Research

Recognizing that translational clinical research is a continuum, the scientific community has defined phases of translational research as T0 through T4 (see chart). At the Center for Pediatric Clinical Effectiveness (CPCE), our investigators work at all levels of translational research.

Preclinical and foundational research, T0, identifies opportunities and approaches to health problems. An example of T0 research from CPCE includes the study of the biomarkers for pediatric sepsis.

T1 level research is designed to move basic discoveries to health applications, such as our work on shared decision-making for pediatric patients with chronic illnesses.

In T2 level research, we test new therapies in controlled settings to provide guidelines for use in clinical settings. CPCE’s work on antimicrobial stewardship is one example of T2 level research.

T3 level research tests the guidelines in real world clinical settings, including CPCE’s investigations of Recognition and  Rapid Response Systems and workload-workforce balance.

And in T4, where we observe factors and interventions that influence health within populations, CPCE is developing databases for clinical effectiveness research and investigating medication safety and effectiveness.

 

Find a research study at CHOP