Karen Puopolo, MD, PhD

Core Faculty

Karen M. Puopolo, MD, PhD is a core faculty member at the Center for Pediatric Clinical Effectiveness (CPCE) and attending neonatologist at The Children's Hospital of Philadelphia (CHOP), and medical director of CHOP Newborn Care at Pennsylvania Hospital.

Dr. Puopolo started her neonatal research career as a laboratory-based scientist investigating mechanisms of virulence in Group B Streptococcus (GBS), an important neonatal pathogen. More recently, her research has focused on the epidemiology of neonatal infection, with an emphasis on molecular epidemiology and risk assessment. She and colleagues developed a risk model for neonatal early-onset sepsis (EOS), which is being incorporated into daily newborn care and has the potential to radically transform the national approach to a rare but potentially life-threatening condition.

Related work correlated EOS risk with complete blood count (CBC), a common laboratory test, based on over 60,000 CBC values. Results of this work were incorporated into 2010 CDC Guidelines for Prevention of Group B Streptococcal Disease.

Contact Dr. Puopolo at puopolok@email.chop.edu.

To view Dr. Puopolo's peer-reviewed publications, click here.